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Iron deficiency remains the most prevalent micronutrient deficiency worldwide. Iron deficiency in TB patients, causes a poor outcome, reccurency, and treatment failure. Iron supplements on TB patients with iron deficiency will activate macrophage-derived monocytes (MDM) and interferon-gamma (IFN-γ), with a positive feedback mechanism pushing interleukin-12 (IL-12). This study is a single-blind randomized control trial comparing the effectivity of preoperative iron supplementation in IL-12 level between two different groups in Dr. Hasan Sadikin General Hospital Bandung, conducted from November 2018 until March 2019. Respondents are those having Spondylitis TB, with sTfR > 21,7 pg/mL and IL-12 21,7 pg/ml dan IL-12< 41 pg/mL. fase intensif OAT kategori 1sesuai dengan standar WHO. Kelompok eksperimen, 17responden diterapi 2 RHZE + tablet iron (III) hidroksi polimaltosa357 mg selama 2 bulan. Kelompok kontrol 17 responden diterapi 2RHZE. Peningkatan IL-12 pada kelompok eksperimen sebesar +364,53% lebih besar dari kelompok kontrol (p<0,05) dan; Penurunan kadar sTfR pada kelompok eksperimen sebesar –60,68% (p<0,05) lebih besar dari kontrol. Uji korelasi sTfR dan IL-12 dengan Pearson ; korelasi -0,763, menunjukkan korelasi kuat antara penurunan sTfR dan kenaikan nilai IL-12. Suplementasi Fe pada terapi preoperatif spondilitis TB dengan defisiensi Fe meningkatkan respon imun yang ditandai dengan meningkatnya IL-12.

Iron as Preoperative Antituberculosis Supplement Increases Interleukin-12 Level in Spinal Tuberculosis and Iron Deficiency Patients