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During September 2–October 4, 2016, four sewage samples collected during August 3–September 19 (Hyderabad, Telangana State, India) and one sewage sample collected on August 30 (Ahmedabad, Gujarat State, India) tested positive for Sabin-like type 2 polioviruses. These polioviruses were detected approximately 4 months after April 25, 2016, when India officially ceased use of trivalent oral poliovirus vaccine (tOPV), containing Sabin attenuated types 1, 2, and 3 polioviruses, and switched to bivalent OPV (bOPV), containing Sabin attenuated types 1 and 3 polioviruses (1). Detection of Sabin-like type 2 poliovirus approximately 4 months after the switch from tOPV to bOPV suggested that tOPV use might have continued after it was supposed to stop globally, creating a risk for emergence of new type 2 vaccinederived polioviruses (VDPV2s), which can cause paralysis. Genetic sequencing of the 903-nucleotide VP1 region of the isolated viruses showed zero, one, two, and four nucleotide changes in the four Hyderabad isolates and one nucleotide change in the Ahmedabad isolate, compared with the type 2 polioviruses in tOPV. These findings indicated that the isolated polioviruses had not replicated sufficiently to accumulate more than a few mutations on a potential pathway to becoming VDPV2s, and that the tOPV they originated from had likely been used during the preceding 4 months. In accordance with global guidelines for responding to poliovirus events (2), detailed investigations were initiated within 48 hours of detection of the type 2 poliovirus in Hyderabad and the neighboring Rangareddy district, and in Ahmedabad (Box). As part of global poliovirus containment efforts (3), laboratories in those areas potentially storing type 2 polioviruses had previously been found to not have such polioviruses, so they were not searched. Telangana and Gujarat state officials met with immunization program stakeholders in the affected districts and other districts in their states regarding the need to reconfirm withdrawal of all tOPV. In Hyderabad and Rangareddy districts, the two main district vaccine cold stores, along with 13 private vaccine retailers and distributors and 4,498 public and private health facilities, were searched during September 4–October 5. Thirty-seven tOPV vials from four manufacturers were found in 17 private clinics; the majority were small clinics not affiliated with an organized medical association. Twenty-two of the tOPV vials were unopened; however, 15 had been partially used. Six vials were beyond their expiration date, and 31 had expiration dates from December 2016 to November 2017. No tOPV vials or bulk type 2 polio vaccine were found at the only vaccine manufacturer in Hyderabad. In Ahmedabad District, the main district vaccine cold store, 572 other cold chain storage points and public and private health facilities, and 12 private vaccine retailers and distributors were searched during September 14–October 17. Two tOPV vials were found at a private vaccine retailer, and another 11 tOPV vials were found at eight private clinics; the majority were small clinics not affiliated with an organized medical association. All tOPV vials had expiration dates ranging from December 2016 to November 2017.

morbidity and mortality weekly report

<i>Notes from the Field</i>: Detection of Sabin-Like Type 2 Poliovirus from Sewage After Global Cessation of Trivalent Oral Poliovirus Vaccine — Hyderabad and Ahmedabad, India, August–September 2016

Notes from the Field: Detection of Sabin-Like Type 2 Poliovirus from Sewage After Global Cessation of Trivalent Oral Poliovirus Vaccine — Hyderabad and Ahmedabad, India, August–September 2016