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This study aims to develop a pragmaticdiscursive analysis of the metaphors deployed in the Spanish newspaper headlines about rare diseases. The corpus comprises the news published during two time periods: from July to September of 2014 (776 articles), and from January to May of 2015 (2,521 articles). The description of the semantics and pragmatics of the metaphors identified in the corpus was performed by combining the predictions from Relevance Theory and from Cognitive Metaphor Theory. A complementary discursive analysis in the framework of Critical Analysis of Metaphor was also conducted. The results showed that the conceptual and expressive content conveyed by two main conceptual metaphors –ILLNESS IS A CONTEST, and ILLNESS IS A JOURNEY– set a specific conceptual and ideological frame to make sense of these illnesses.

Vaguedad y relevancia: metáforas en los titulares de prensa sobre las enfermedades poco frecuentes