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"Even numbers are the sum of two prime numbers." This is the description of Goldbach's conjecture, and in Canadian Gaye's book "unsolved problems in number theory", it is an open question to put forward a contrary conjecture that "even numbers are the difference between two prime numbers". In this paper, Chandra sieve is used to deduce that the sum of large and even numbers is the sum of two prime numbers, and that "even numbers are the difference between two prime numbers" is a great possibility. At the same time, it is possible to guess the possibility of twin prime conjecture.