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Open a cess: www.balimedicaljournal.org and ojs.unud.ac.id/index.php/bmj The combination effect of brisk walking and relaxation toward hs-crp and anxiety levels in subject with central obesity in Singaraja, Bali Ketut Indra Purnomo1,2*, Muchsin Doewes2, Suroto2, Bhisma Murti2 Background: Inflammation and anxiety have reciprocal relationships because low grade chronic inflammation characterized by elevated hs-CRP in central obesity has been proved to induce anxiety. Likewise, anxiety could also induce central obesity and inflammation of peripheral tissue. Brisk walking and relaxation have been proved to have anti-inflammatory effects. However, the effects of their application in central obesity population have not been observed. Objective: The aim of the study is to determine the combination effect of brick walking and relaxation on hs-CRP and anxiety level. Method: This research is an experimental research with randomized controlled trial design. According to sample size formula, this study required 80 with central obesity which would be selected using purposive sampling. The sample was divided into 4 groups by randomization procedure intocontrol group, brisk walking group, relaxation group and combination of brisk walking and relaxation group. Each group was given thrice a week treatment for six weeks. Data were analyzed by using SPSS 22. Results: A total of 80 samples with central obesity were enrolled with mean age 47.66 ± 7.47 years old and WHtR 0.57 ± 0.04. There is no significant effect of brisk walking, relaxation, and their combination to hs-CRP level (p = 0.696). On the other hand, all of the interventions were significantly reduce the anxiety level. However, the combination of brisk walking and relaxation had the most significant effect in decreasing anxiety level even when compared to either brisk walking or relaxation group (p <0.05). Conclusion: Both brisk walking and relaxation significantly reduce the level of anxiety but their combination had the most significant effect. However, no intervention had proved to alter the level of hsCRP.