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Open access: www.balimedicaljournal.org and ojs.unud.ac.id/index.php/bmj The antiplasmodial activity of chalcone derivative through the inhibition of haemozoin formation and the induction of stomatocytes formation Lilik Wijayanti1, Kristanto Yuli Yarso2, Bambang Purwanto3, Ambar Mudigdo4, Hery Suwito5, Paramasari Dirgahayu6, Mustofa7* Background: One of methoxy aminochalcone derivatives, (E)-1(4-aminophenyl)-3-(2,3-dimethoxyphenyl)prop-2-en-1-one has been synthesized and proven it’s in vitro antiplasmodial activity. In this study, we reported in vivo antiplasmodial activity of this compound against Plasmodium berghei infected mice. Its effect on the haemozoin and erythrocytes stomatocytes formations was also