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Background: Oxidative stress occurs when free radicals levels are higher than antioxidants levels. This can trigger cell damage which leads to various diseases such as Alzheimer, atherosclerosis, and degenerative diseases such as heart disease, cancer, and premature aging. Oxidative stress can be caused by excessive physical activities. Dewandaru fruit (Eugenia uniflora L), which contains high levels of antioxidants such as phenol, flavonoid, and anthocyanin, can prevent excessive oxidation caused by maximum physical activities. This research aims to test the activity of Dewandaru fruit extract in reducing oxidative levels. Methods: This study used purely experimental planning of posttest only control group design. Twenty-four rats were divided into four groups; control group, P1, P2, and P3. All groups were given maximal physical exercise. The P1, P2, and P3 received 50 mg/kgBW, 100 mg/kgBW, and 200 mg/kgBW of n-butanol extract of Dewandaru fruit respectively. Measurement of Malondialdehyde (MDA), F2isoprostane, 8-OHdG, and superoxide dismutase (SOD) with ELISA was used to determine the level of oxidative stress. Result: The levels of MDA, F2-isoprostane, and 8-OHdG were higher in control group when compared to the treatment group; a higher dose of the extract resulted in lower MDA, F2-isoprostane, and 8OHdG levels (p  = 0.001). While the level of SOD was lower in the control group when compared to the treatment group; a higher dose of the extract resulted in a lower SOD level (p = 0.001). Conclusion: N-butanol extracts of Dewandaru fruit at a dose of 50 mg/kgBW, 100 mg/kgBW, and 200 mg/kgBW significantly reduce MDA, Isoprostane, 8-OhdG and increase SOD in rats given maximum physical activities.

Dewandaru fruit extracts (Eugenia uniflora L) reduce oxidative stress and increase Superoxide Dismutase level in excessive activity-induced rats