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Recent studies have suggested the presence of a genetic isolate in the village of Runta, located in the department of Boyaca, Colombia, given the finding of a larger number of patients with rare diseases than expected for this population. This finding indicates the probability of an increased rate of inbreeding in this community. Objectives: To determine inbreeding parameters using isonymy to analyze the population structure of this village and to help elucidate the causes of these diseases. Materials and methods: Six parameters indicative of population structure were established based on the surnames registered in the database of the Potential Beneficiaries of Social Programs Identification and Selection System of the inhabitants of Runta. Results: Results showed an inbreeding coefficient (θii) of 0.0083, Fisher’s alpha (α) of 30.0447 and A, B and C estimates of 0.0379, 0.3413 and 0.4669, respectively. Most individuals had the most popular surnames of the village, while isonymy parameters in Runta were found to be similar to those of isolated communities previously described in the literature. Conclusion: These results support the hypothesis that there is indeed a genetic isolate located near the capital of the department of Boyaca.

Determinación de endogamia mediante método de isonimia en la población de Runta, Boyacá, Colombia