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The effect of intact blood lymphocytes from conditionally healthy persons on the genome stability in blood lymphocytes of patients with primary diagnosis of B-cell chronic lymphocytic leukemia (CLL) exposed in vitro to γ-quanta 137Cs at the G0 stage of the cell cycle in a dose of 0.5 Gy was investigated. For the study, the own model system of co-cultivation of blood lymphocytes from persons with different genders that permit to study va rious manifestations of the bystander response phenomenon at the cytogenetic level was used. The decrease in the radiation-induced total frequency of chromosome aberrations in irradiated cells of patients with CLL (from 12.88 till 9.56 per 100 metaphases, p   0.05). The obtained data indicate that the result of the interaction between irradiated in vitro blood cells of patients with B-cell CLL (target cells) with intact blood lymphocytes of relatively healthy individuals (bystander cells) is a decrease of the chromosome instability in target cells, which is similar to the radiation-induced rescue effect type one.

dopovidi nacionalʹnoï akademiï nauk ukraïni/dopovìdì nacìonalʹnoï akademìï nauk ukraïni

Realization of the rescue effect at the cytogenetic level due to the interaction between intact normal and irradiated malignant human blood lymphocytes