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Cortisol secreted by the adrenal cortex is an important hormone related to inflammation and stress. Cortisol levels increase in goats after 8 h of surgical procedure, being significant (p<0.05) and after 72h, the level decreases drastically.1 Cortisol levels in goats ranges 14-18ngmL.2 The type of anesthetic block may also influence the amount of blood cortisol in animals,3 as well as temperature and estrous in goats, interfering directly with exogenous melatonin.4 The endocrine response is one of the physiological mechanisms to respond to stress in the temperature levels and is a mechanism of homeostasis defense, increases with body temperature, however melatonin regulates the level of cortisol. In addition, melatonin regulates cortisol and TSH levels in goats and the findings reveal that there is an interaction of melatonin with cortisol in goats,4 melatonin directly inhibits the adrenal gland for ACTH.5 The stimulatory effect of light through the eye on the expression of the adrenal gland gene causing plasma corticosterone and release without activating the hypothalamic-pituitary-adrenal axis,6 and it may be speculated that melatonin interferes in the gene by reducing the level cortisol secretary. In humans melatonin and cortisol oppose themselves during 24h, while cortisol is low early in the morning, melatonin peaks at this time, with a circadian rhythm of reproducibility for six weeks.7 Blind individuals there are no melatonin profile and the cortisol does not appear in saliva and can be altered by stress or sleep disorders. Its concentration is present upon awakening (8-10ha.m.).8 Goats show period of reproductive and anestrous seasonality in different latitudes, north and south, and depends when they are distanced from the equator line, and males can prevent this seasonal anestrous. The reduction of the light period is detected by the retina, the suprachiasmatic nucleus, by sympathetic neurons, via the pineal gland, producing melatonin and neurotransmitters (dopamine, serotonin and other amino acids),

Melatonin, cortisol and progesterone in alpine goat’s superstimulateds with FSH-OV and artificial photoperiod