English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

OBJECTIVES: To determine the presence of p53 mutations among patients with colorectal carcinoma and their relationship with the tumoral size and with Dukes’ stage classification. MATERIALS AND METHODS: Anatomopathological specimens of 40 cases of colorectal carcinoma from the Hospital Central FAP, taken between 1987 and 1996, were re-examined. For detecting p53 protein mutations, the streptavidin-biotin immunoperoxidase immunohistochemical assay with do-7 antibody was used, pre-processing the samples with microwaves. RESULTS: All cases were adenocarcinomas, mostly moderately differentiated; 18 were in Dukes B, 16 Dukes in C, 4 in Dukes A and 2 in Dukes D stage. Tumoral size was directly related with Dukes’ stage, having a mean size of 5,5 cm3 for Dukes A, and 50,12 cm3 for Dukes D. There was a presence of p53 mutation in 55% of cases; the higher p53 expression, both the higher Dukes’ stage (a = 0,353) and the higher tumoral size (a = 0,376). CONCLUSION: Among our cases, p53 mutation accumulation was directly related with tumoral size and Dukes’ stage.

Asociación entre la Proteína p53 Mutada, Grado de Infiltración y Tamaño del Tumor en Cáncer Colorrectal. Hospital Central Fap 1987-1996