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The effect of the chloroform extract of Tripterygium wilfordii Hook f (TWH) on inflammatory mediator production was examined in vivo in BALB/c mice. Autoclaved Teflon chambers (30 X 10 mm) were implanted into the backs of BALB/c mice. After 10 days, 1 % zymosan A in a volume of 300 i 1 was injected into the chamber to induce local inflammatory responses. Exudate fluid in the chamber was withdrawn at various intervals after zymosan injection to measure the levels of inflammatory mediators, interleukin-1 ƒÀ, tumor necrosis factora and prostaglandin E2. After zymosan injection, levels of inflammatory mediators increased rapidly, reached maximums 1 to 2 days later, then slowly decreased to baseline levels. Oral treatment with TWH extract 2 hours before zymosan injection reduced in a dose-dependent manner concentrations of both interleukin-1 i and tumor necrosis factora in exudate fluid obtained from mice 24 hours after injection. However, TWH extract reduced prostaglandin E2 concentrations at only the highest dose used.

showa university journal of medical sciences

Effect of Tripterygium wilfordii Hook f, a Chinese Traditional Herb, on Macrophage Function in Mice, II. Inhibition of Inflammatory Mediator Production in vivo