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Background: Decrease of muscle strength around knee and ankle are considered to contribute several movement disorders in diabetic patient such as an increased risk of falling, altered gait and balance, and increased body sway. In this study, we examine the effect of exercise training on skeletal muscle of type 2 diabetic models. Methods: Otsuka Long–Evans Tokushima fatty (OLEFT) rats, type 2 diabetic models, were divided into an exercise training group (OLETF-EX, n = 3) and a sedentary group (OLETF-SED, n = 3), while Long– Evans Tokushima Otsuka (LETO) rats were used as a control group (LETO-SED, n = 4). The OLETF-EX rats were trained on a treadmill five times a week for 15 weeks. Data were subjected to two-tailed multiple t-tests with Bonferroni correction following an ANOVA. Results: The muscle force per body weight was significantly lower tension in MG muscle of OLETFSED animals than LETO-SED animals. On the other hand, twitch tensions of OLETF-EX animals were preserved. Conclusion: These data suggest that exercise training prevent decrease of muscle strength in type 2 diabetic model.

Exercise Training Prevent Decrease of Muscle Strength in Otsuka Long- Evans Tokushima Fatty Rats: A Preliminary Study