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Cultural sensitivity provides one of the foundations for a successful clinical research within tribal communities. Researchers involved in the efforts that cross paths with cultural practices of human subjects must be aware of the potential impact as well as the challenges these will pose to the clinical research process. These were some of the insights gained from the research experience of the biomedical research team from University of Guam (UOGCRC) and the University of Hawai’i (UHCC) after conducting a study in Guam which aimed to describe the betel nut chewing practices of its indigents and identify specific biomarkers that occur in the saliva of humans after betel nut (BN) mastication.

Cultural Considerations in the Conduct of Clinical Research: The Guam Experience