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The aim of this study was to evaluate the cytotoxicity of cadmium chloride (CdCl2), toxicant, and the protective effect of Chelidonium majus (CM) extract on CdCl2-induced cytotoxicity in cultured NIH3T3 fibroblasts. Cell viability, the effect of butylated hydroxytoluene (BHT) against CdCl2, and the antioxidative effects including DPPH-free radical scavenging activity, superoxide anion-radical scavenging activity (SSA), and lactate dehydrogenase (LDH) activity were assessed. CdCl2 caused a significant dose-dependent decrease in cell viability, and XTT50 value was determined at 38.7 uM of CdCl2. It was determined as highly-toxic by Borenfreund and Puerner' toxic criteria. BHT of antioxidant significantly increased cell viability severely damaged by CdCl2-induced cytotoxicity in these cultures. In the protective effect of CM extract on CdCl2-induced cytotoxicity, CM extract significantly increased cell viability, DPPH-free radical scavenging activity, SSA and inhibitory activity of LDH. From these results, it is suggested that oxidative stress is involved in the cytotoxicity of CdCl2, and CM extract showed protective efficacy on CdCl2-induced cytotoxicity via antioxidative effects. Conclusively, natural resources like CM extract may be a putative antioxidative agent for the detoxification or diminution of toxicity correlated with oxidative stress.

Antioxidative Effect of Chelidonium majus Extract on Cultured NIH3T3 Fibroblasts Injured by Cadmium Chloride of Toxicant