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Conclusions. Combined clinical and gene expression analysis of human ACTH-secreting adenomas allowed the identification of three major clusters. Functional annotations revealed the involvement of distinct pathways in individual clusters, paving the way to a greater understanding of the variability of human corticotrope tumors. Results Aim of this study is to correlate transcriptome expression pattern in archival human ACTH-secreting adenomas with clinical features of patients prior to and after surgery.

Combined clinical and gene expression profiling in human ACTH-secreting pituitary tumors