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Muge Bilge DOI: 10.3252/pso.eu.17ece.2015 Diabetes (complications & therapy) Muge Bilge MD1, Mine Adas MD2, Recep Yilmaz Bayraktarli3, Aysen Helvaci MD1 1Okmeydani Education and Research Hospital, Internal Medicine, Istanbul, Turkiye 2Okmeydani Education and Research Hospital, Endocrinology, Istanbul, Turkiye 3Okmeydani Education and Research Hospital, Radiology, Istanbul, Turkiye BACKGROUND: Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE syndrome) is a very rare clinical entity including a tenosynovitis of the hands and wrists, and marked pitting edema on upper and lower extremities. RS3PE has been suggested to be associated with many disease conditions and drugs. Saxagliptine is DPP4 inhibitor that relatively new oral hypoglycemic agent. This case is the second report of the occurrence of RS3PE in patients receiving a DPP4 inhibitor.

Remitting seronegative symmetrical synovitis with pitting oedema syndrome in association with saxagliptine: case report