Urotensin-II is present in pancreatic extracts and inhibits insulin release in the perfused rat pancreas | Zendy

RA Silvestre | Zendy; EM Egido | Zendy; René Delgado | Zendy; Jérôme Leprince | Zendy; David Chatenet | Zendy; H. Tollemer | Zendy; Nicolas Chartrel | Zendy; Hubert Vaudry | Zendy; José Marco | Zendy

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Urotensin-II is present in pancreatic extracts and inhibits insulin release in the perfused rat pancreas

Author(s) -

RA Silvestre,

EM Egido,

René Delgado,

Jérôme Leprince,

David Chatenet,

H. Tollemer,

Nicolas Chartrel,

Hubert Vaudry,

José Marco

Publication year - 2004

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1510803

Subject(s) - urotensin ii , endocrinology , medicine , agonist , insulin , receptor , chemistry , biology

Previous work from our laboratory has demonstrated that frog urotensin-II (UII), at a high concentration, inhibits glucose-induced insulin release in the rat pancreas. We have investigated the effect of rat UII and two structural analogs on insulin secretion and searched for the presence of UII-immunoreactivity in rat pancreatic extracts.

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