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Low total testosterone (TT) serum concentrations in men have been associated with various cardiometabolic risk factors. But given error-prone immunoassays used for TT assessment, upcoming mass spectrometry methods question the validity of these risk associations. Thus, we performed the first comparative study quantifying potential differences in the association of TT with cardiometabolic risk factors between the two methods.

european journal of endocrinology

Testosterone and cardiometabolic risk in the general population – the impact of measurement method on risk associations: a comparative study between immunoassay and mass spectrometry