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Genome-wide association studies have shown that the melatonin receptor 1B (MTNR1B) gene locus is strongly associated with fasting glucose and β-cell function. However, data are rather limited to the adult population and normal-weight children. So far, little is known whether similar associations are present in overweight and obese children and adolescents.

Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS