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In this study, we prepared liquid crystal emulsion composed of amphiphilic substance C14-22 alcohol, C12-20 alkyl glucoside, behenyl alcohol and studied liquid crystal emulsion of properties and in vitro skin permeation. The results of formulation experiments, the clear liquid crystalline structure was observed in the ratio of C14-22 alcohol 0.8%, C12-20 alkyl glucoside 3.2%, behenyl alcohol 4% in the formulation. The results of physical property measurements, the viscosity of liquid crystal emulsion and O/W emulsion applied as a control group was respectively 1871.26 ∼ 1.15 Pa⋅s, 1768.69 ∼ 1.14 Pa⋅s and the shear stress of O/W emulsion was 178.68 ∼ 909.18 Pa, that of liquid crystal emulsion was 190.45 ∼ 919.38 Pa. The storage modulus of O/W emulsion was 3428.53 ∼ 9157.45 Pa, that of liquid crystal emulsion was 4487.82 ∼ 8195.59 Pa. The tan (delta) value of O/W emulsion which means a ratio of viscosity to elasticity was 0.43 ∼ 0.19, and that of liquid crystal emulsion was 0.23 ∼ 0.25. The water content value on the skin for liquid crystal emulsion was significantly higher from 1 h to 6 h compared with that of O/W emulsion and the transepidermal water loss on the skin was significantly superior in skin moisture loss suppression from 30 min to 4 h compared with that of O/W emulsion. The results of skin permeation using glycyrrhizic acid, the result of skin permeation amount of liquid crystal emulsion for 24 h was 64.58 μg/cm2, that of O/W emulsion was 37.07 μg/cm2, that of butylene glycol solution was 41.05 μg/cm2. Hourly permeability results, it is showed that skin penetration effect of the liquid crystal emulsion increases after 8 h. These results suggest that liquid crystal emulsions are effective for skin moisturizing effect and function as potential efficacy ingredient delivery system for the transdermal delivery.

Preparation of Liquid Crystal Emulsion for Transdermal Delivery of Glycyrrhizic Acid and Physical Characteristics and In Vitro Skin Permeation Studies