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Long-term modification of synaptic transmission at corticostriatal synapses is implicated in voluntary motor control, reward-based learning, and habit formation ([Reynolds and Wickens, 2002][1]; [Yin and Knowlton, 2006][2]). Unlike many excitatory synapses in the brain that are potentiated by high-

A Molecular Switch for Induction of Long-Term Depression of Corticostriatal Transmission: Figure 1.