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The e4 allele of apolipoprotein E (APOE) is the strongest genetic risk factor for the development of Alzheimer's disease (AD). Accumulation of amyloid-β (Aβ) is hypothesized to initiate synaptic and neuronal dysfunction that ultimately lead to neuronal cell death in AD, and several lines of

Differential Effects of ApoE Isoforms on Dendritic SpinesIn Vivo: Linking an Alzheimer's Disease Risk Factor with Synaptic Alterations