English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In recent years, evidence has accumulated that non-Mendelian transgenerational inheritance of qualities acquired through experience is possible. In particular, it has been shown that raising rodents in a so-called enriched environment (EE) can not only modify the animals' behavior and increase their susceptibility to activity-dependent neuronal network changes, but also influences both behavior and neuronal plasticity of the non-enriched offspring. Here, we tested whether such a transgenerational transmission can also be observed in the primary visual cortex (V1) using ocular dominance (OD) plasticity after monocular deprivation (MD) as a paradigm. Whereas OD plasticity after 7 d of MD is absent in standard-cage (SC) raised mice beyond postnatal day (P)110, it is present lifelong in EE-raised mice. Using intrinsic signal optical imaging to visualize cortical activity, we confirm these previous observations and additionally show that OD plasticity is not only preserved in adult EE mice but also in their adult non-enriched offspring: mice born to enriched parents, but raised in SCs at least until P110 displayed similar OD shifts toward the open eye after 7 d of MD as age-matched EE-raised animals. Furthermore, testing the offspring of EE-female versus EE-males with SC-mating partners revealed that only pups of EE-females, but not of EE-males, preserved OD plasticity into adulthood, suggesting that the life experiences of the mother have a greater impact on the continued V1 plasticity of the offspring. The OD plasticity of the non-enriched pups of EE-mothers was, however, mechanistically different from that of non-enriched pups of EE-parents or EE mice.

Transgenerational Transmission of Enhanced Ocular Dominance Plasticity from Enriched Mice to Their Non-enriched Offspring