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The reaction of 6-hydrazinyl-1,3-dimethylpyrimidine-2,4-(1H,3H)-dione () with ethoxymethylenemalononitrile afforded 5-amino-1-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin- 6-yl)-1H-pyrazole-4-carbonitrile ( 2 ). The latter was reacted with formamide and urea affording the corresponding 4-aminopyrazolo[3,4-d]pyrimidines  3  and  4 . The reaction of monosaccharide aldoses with  3  and  4  gave stereoselectively the β-N-glycosides  5a  -  d  and  6a  -  d  which were treated with acetic anhydride in pyridine to afford the corresponding acetylated derivatives  7a  -  d  and  8a  -  d . The prepared compounds were tested for their antiviral activity against hepatitis B virus (HBV) and showed moderate to high activities

Anti-Hepatitis B Virus Activity of New N 4 -β-D-Glycoside Pyrazolo[3,4-d]pyrimidine Derivatives