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Four new platinum(II) complexes of 3-aminocyclopentanespiro-5-hydantoin (acpsh) and 3-aminocycloheptanespiro-5-hydantoin (achpsh) were synthesized and characterized by elemental analysis, IR and  1 NMR spectra. The spectral analyses indicated a cis-square planar structure of the complexes with ligands coordinated via the NH 2  group. The complexes were evaluated for in vitro cytotoxicity in murine erythroleukemia (MEL) cells, clone F4N, using cell-growth and macromolecular synthesis assay. The compounds, with exception of [Pt(NH 3 )(achpsh)Cl 2 ] (IV), exhibited much lower cytotoxicity than that of cisplatin (DDP). Compound IV was nearly as cytotoxic as DDP. The new complexes exerted low antibacterial activity as assessed by seven bacterial strains

Synthesis and Cytotoxicity of Platinum(II) Complexes of 3-Aminocyclopentanespiro- 5-hydantoin and 3-Aminocycloheptanespiro-5-hydantoin