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The effects of different a-D-Glucose (Glu) concentrations (0 -16 mᴍ) on Na + , K + -ATPase and Mg 2+ -ATPase activities were investigated in homogenates of adult male rat whole brain at 37 °C. The enzyme activities were determined after 1h preincubation with Glu. Brain Na + , K + -ATPase was not affected by Glu different concentrations. On the contrary, Mg 2+ -ATPase activity was considerably reduced with Glu concentrations lower than 4 mᴍ. The enzyme was inhibited 40%, 50% or 80% with 3, 2 or 1 mᴍ of Glu, respectively. The above results suggest: a) The various concentrations of Glu have no effect on brain Na + , K + -ATPase activity, b) The inhibited brain Mg 2+ -ATPase in hypoglycemia produces low intracellular Mg 2+ , which could modulate the activity of Mg 2+  -dependent enzymes and the rates of protein syn­thesis and growth of the cell.

Reduced Mg 2+ - ATPase Activity in the Hypoglycemic Adult Rat Brain