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The antimicrobial activity of fifteen semisynthetic labdane-type diterpenes derived from the two major natural compounds 3 and 4 of the resin "ladano" of Cistus creticus is reported. The chloroethyl carbamidic esters 15 and 20 showed the strongest antimicrobial activity against Gram (+), Gram (-) bacteria and pathogenic fungi.

New Semisynthetic Antimicrobial Labdane-Type Diterpenoids Derived from the Resin “Ladano” of Cistus creticus