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Chemical and enzymatic procedures are described for the synthesis of the monophosphates and cyclic phosphates of the antiviral acyclonucleoside 9-(1,3-dihydroxy-2-propoxym ethyl)-guanine (DHPG), its 3-hydroxymethyl-4-hydroxybutyl analogue, the (/?)-and (S)-epimers of 9-(3,4-dihydroxybutyl)guanine, and 9-(2,3-dihydroxypropyl)guanine.

zeitschrift für naturforschung c

Monophosphates and Cyclic Phosphates of Some Antiviral Acyclonucleosides: Synthesis, Conformation and Substrate/Inhibitor Properties in Some Enzyme Systems