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Gibberelline, prednisolon and benzpyrene stimulated the growth of Tetrahymena at the first interaction, while epinephrine did not. On a second exposure following upon the first 24 h treatment after a rest period of 6 h, epinephrine, too, developed a stimulatory action, and the other three molecules gave rise to a still greater increase in the growth rate. Obviously, imprinting effected by the first interaction accounts for a greater responsiveness to physio­ logical materials (hormones) also if these are indifferent in respect of the given function, and non-physiological, but biologically active materials can also give rise to imprinting in exposed target cells.

zeitschrift für naturforschung c

"Memory" of First Interaction with Physiological or Biologically Active Foreign Molecules (Benzpyrene, Gibberelline) in a Unicellular ( Tetrahymena) Model System