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In this work, new derivatives of the  β -sitosterol scaffolds containing 1,2,3-triazole are prepared by the reaction of  β -sitosterol with aromatic alkynes via copper(I)-catalyzed azide-alkyne cycloaddition reactions under microwave irradiation. The reaction has several advantages including high yields, short reaction times, and a simple work-up procedure.

Efficient synthesis of novel β -sitosterol scaffolds containing 1,2,3-triazole via copper(I)-catalyzed click reaction under microwave irradiation