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A new gentisic acid derivative named micronyc acid ( 1 ) and a new 1,4-benzoquinone derivative named micronone ( 2 ) have been isolated from the root of  Micronychia tsiramiramy  together with the known compounds gallic acid ( 3 ), methyl gallate ( 4 ), moronic acid ( 5 ), masticadienolic acid ( 6 ), and masticadienediol ( 7 ). The structures of  1  and  2  were established using MS and NMR. Compound  1  was tested for antiplasmodial activity  in vitro  against the chloroquine-resistant strain  Plasmodium falciparum  W2 and displayed moderate antiplasmodial activity  in vitro  with an IC 50  value of 25.6  μ  m . Compounds  1  and its acetyl derivative  1a  were also tested for their cytotoxicity against the human cervix carcinoma cell line KB-3-1 and still showed moderate activity.

Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae)