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A mixture of two compounds with potent antiplasmodial activity  in vitro  against the W2 strain of  Plasmodium falciparum  (half maximal inhibitory concentration, 1.12 μg/mL) was obtained in a previous investigation of the CH 2 Cl 2 -MeOH extract of the seeds of  Salacia longipes  var.  camerunensis.  Separation by column chromatography led now to the isolation of salaterpene E ( 1 ) and (1 R ,2 R ,4 S ,5 S ,6 R ,7 R ,9 S ,10 R )-2-acetoxy-1,6,9-tribenzoyloxy-4-hydroxy-dihydro- β -agarofuran ( 2 ). The structure of  1  was elucidated by spectroscopic analysis, and its absolute configuration was established unambiguously by means of single-crystal X-ray diffraction. Also the absolute configurations of the recently described salaterpenes A ( 2a ) and D ( 2b ) were determined by this method using the anomalous scattering of the oxygen atoms only.

Salaterpene E, a eudesmane-type sesquiterpene from Salacia longipes var. camerunensis