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Cyclocondensation reaction of ethyl 7,8-diamino-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline- 3-carboxylate (2) or the -3-carboxylic acid 3 with sym-1,2- diketones produced the corresponding ethyl 2,3-disubstituted pyrido[2,3- f ]quinoxaline-8-carboxylates (4a - h) or the -8-carboxylic acids 5a - h, respectively. The structures for these new heterocycles are supported by analytical and spectral (IR, MS, NMR) data. Compounds 5a - c, g, h exhibit moderate activity against an assortment of bacterial species.

zeitschrift für naturforschung b

Heterocycles [h]-Fused onto 4-Oxoquinoline-3-carboxylic Acid, V [1]. Synthesis and Antibacterial Activity of Some New 2,3-Disubstituted 7-Oxo-7,10-dihydropyrido[2,3-f]quinoxaline-8-carboxylic Acids and Esters