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Cannabidiol 3 has been synthesized under high pressure conditions (7-8 kbar, 150 °C) from Olivetol 1 and trans-p-Menthadien-(2,8)-ol-(1) 2 with 41% yield. The influence of different solvents on the yield has been studied.

zeitschrift für naturforschung b

Hochdruckreaktionen, XIII [1] Synthese von(—)Cannabidiol unter hohen Drucken / High Pressure Reactions, XIII [1] Synthesis of (—) Cannabidiol at High Pressure