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Objectives It was aimed to investigate if there were any significant corresponding changes on adipokine levels in obese subjects who achieved a 10% reduction in body weight. Methods Thirty obese and 25 healthy adults were enrolled in present study, and serum levels of vaspin, apelin-13, obestatin, and insulin were determined with the ELISA method. Results The serum obestatin and apelin-13 values of the obese group obtained as basal and after weight loss was significantly lower than in controls (p 0.05). The vaspin level did not differ between the groups (p&gt;0.05). The obese group had characterized increased serum insulin and insulin resistance assessment by the homeostatic assay (HOMA-IR) levels compared to controls (p 0.05). Conclusions Obese individuals exhibited decreased levels of apelin-13 and obestatin. Moreover, 10% weight loss caused a significant reduction of insulin resistance, but no significant change was detected on apelin-13, obestatin, and vaspin levels.

The investigation effect of weight loss on serum vaspin, apelin-13, and obestatin levels in obese individual