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Rhodium-103m is one of the most attractive Auger electron emitters for internal radiotherapy. The half-life of  103m Rh is relatively short (56.114 min). Therefore, it needs to be produced using a generator for clinical use. Most studies of  103 Pd/ 103m Rh generators using anion-exchange resins were carried out over 50 years ago. However, these resins are no longer commercially available. In the present study, we tested a  103 Pd/ 103m Rh generator using alternative anion-exchange resins (i.e., IRA904, IRA410, SA20A, and SA11AL). No-carrier-added  103 Pd was used to make the generators. The  103m Rh product was eluted from the generators using 6 mL of 0.1 M HCl with a flow rate 0.5 mL/min. The generator made from SA11AL showed good performance, with a yield of 39 %, an impurity level of  103 Pd in the product of 0.29 %, and an operation time of 14 min. This makes this generator competitive with previously developed ones.

Production of Auger-electron-emitting 103m Rh via a 103 Pd/ 103m Rh generator using an anion-exchange resin