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This study presents development and characterization of a radiotracer, [ 125 I]iodonefiracetam ([ 125 I]iodoNEF). Labeling with high yield and radiochemical purity was achieved through the formation of a [ 125 I]iodoNEF radiotracer after investigating many factors like oxidizing agent content (chloramines-T (Ch-T)), substrate amount (Nefiracetam (NEF)), pH of reaction mixture, reaction time and temperature. Nefiracetam (NEF) is known as nootropic agent, acting as  N -methyl- d -aspartic acid receptor ligand (NMDA). The radiolabeled compound was stable, and exhibited the logarithm of the partition coefficient (log  p ) value of [ 125 I]iodonefiracetam as 1.85 (lipophilic). Biodistribution studies in normal mice confirmed the suitability of the [ 125 I]iodoNEF radiotracer as a novel tracer for brain imaging. High uptake of 8.61 ± 0.14 percent injected dose/g organ was observed in mice

In silico and in vivo study of radio-iodinated nefiracetam as a radiotracer for brain imaging in mice