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The use of α-emitting radionuclides in targeted alpha therapy (TAT) holds great potential for treatment of human diseases, such as cancer, due to the short pathlength and high potency of the α particle, which can localize damage to targeted cells while minimizing effects to healthy surrounding tissues. In this review several potential α-emitting radionuclides having emission properties applicable to TAT are discussed from a radiochemical point of view. Overviews of production, radiochemical separation and chelation aspects relative to developing TAT radiopharmaceuticals are provided for the α-emitting radionuclides (and their generator systems)  211 At,  224 Ra/ 212 Pb/ 212 Bi,  225 Ac/ 213 Bi,  227 Th/ 223 Ra,  230 U/ 226 Th,  149 Tb and  255 Fm.

Radiochemical aspects of alpha emitting radionuclides for medical application