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In the present paper the synthesis and structural characterization of alkaline-earth metal(II) complexes of the polyether ionophorous antibiotic salinomycinic acid (SalH.H 2 O) are discussed. The complexes [M(Sal) 2 (H 2 O) 2 ] (M = Mg 2+ ,  1 ; Ca 2+ ,  2 ; Sr 2+ ,  3 ; Ba 2+ ,  4 ) were obtained reacting salinomycinic acid and Et 4 NOH with the corresponding metal(II) salts at metal-to-ligand-to-base molar ratio of 1:1:1. The spectral properties of  1–4  were characterized using infrared spectroscopy, fast atom bombardment-mass spectrometry, nuclear magnetic resonance and elemental analysis data. The crystallinity degree and morphology of complex  2  were studied by X-ray powder diffraction and transmission electron microscopy. The biometal(II) salinomycinate complexes  1  and  2  possess an enhanced antimicrobial activity compared to the parent antibiotic against Gram-positive bacteria. The comparison between the effectiveness of the complexes, reported here, and the already known isostructural coordination species of salinomycin and monensin (MonH.H 2 O), revealed that magnesium(II) and calcium(II) monensinates appear to be promising antibacterial agents against  Bacillus subtilis ,  Bacillus cereus  and  Micrococcus luteus .

Alkaline-earth metal(II) complexes of salinomycin – spectral properties and antibacterial activity