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Oral sclerotic chronic graft-versus-host-disease (cGvHD) represents a distinctive phenotype of cGvHD which causes severe disability and morbidity due to impaired oral hygiene and food intake, jaw pain, tightness and discomfort. As it is a rare presentation, there is little published evidence on its management. Here, the case of a patient suffering from stage-2 oral sclerotic cGvHD treated with a bilateral surgical release of fibrous bands performed using a blue light-emitting diode laser (λ=445±5 nm) is presented. This was followed by maintenance of the mouth opening through a specifically designed resin intraoral device. After the laser-assisted surgical procedure, the patient did not experience any bleeding, pain or discomfort, and the mouth opening was increased from 12 mm to 20 mm. Over a 6-month follow-up period, the patient increased and stabilized the mouth opening from 20 mm to 25 mm helping to maintain and improve oral hygiene together with overall comfort and quality of life.

Laser surgical treatment of chronic graft-versus-host disease (cGvHD)-induced buccal mucosal sclerosis