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A method of diffuse optical tomography (DOT) is described for the direct detection of absorbing and scattering inhomogeneities such as cysts, hematoma, or tumors. DOT can also be used to detect small changes in the oxygenation and deoxygenation of blood in designated regions of the heads of neonates, and in breast cancer. In contrast to the early part of time-resolved transmittance of a femtosecond pulse, late-arriving photons are used for this purpose. A 2D numerical simulation is used for quantitative matching of diffuse model curves to experimental data. The finite difference method is used for computer simulation of movements of a cloud of photons from the surface of an object to its center. The 3D representations of the time point spread functions (TPSF) represent a flat surface in a homogeneous case. Lower parts of the surface indicate the presence of inhomogeneities at the corresponding angles.

Early- and late-arriving photons in diffuse optical tomography/Früh und spät ankommende Photonen in der diffusen optischen Tomographie