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Two new diorganotin(IV) complexes with the general formula (RC 7 H 6 ) 2 Sn(L) (where RC 7 H 6  =  p -ClBn,  C1 ; and  p -FBn,  C2 ) were prepared based on the reaction of 2,3- bis (4-hydroxysalicylidene-amino)-maleic nitrile ( L ) with substituted dibenzyltin(IV) dichloride. The structures were confirmed by elemental analysis, Fourier transform infrared (FT-IR), proton and carbon nuclear magnetic resonance ( 1 H and  13 C NMR). They were tested against several cancer cell lines by using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.  C1 , which was most effective against MCF-7 breast cancer cell line, was further investigated in formulation and encapsulation studies, including drug encapsulation efficiency, particle size, morphology and  in vitro  drug release. An encapsulation of about 90% was achieved with particles of 128 nm average diameter. Field emission scanning electron microscopy (FESEM) confirmed a spherical shape for the encapsulated  C1 . The cumulative drug release over a period of 60 days in phosphate buffered saline (PBS) at pH 7.4 was 75%. Based on these results, the formulated drug has the potential of a slow release drug for cancer chemotherapy.

main group metal chemistry

Synthesis, structural characterization, cytotoxicity and encapsulation studies of  N , N ʹ-(1, 2-dicyano-1,2-vinylene)- bis (4-hydroxysalicylideneaminato) di( p -chlorobenzyl)tin as potential anticancer drug