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The trial was performed on 10 clinically healthy Ross hybrid chickens, 5 from each gender, weighing 2.75-2.84 kg. The tested quinolone was applied at the same dose for both routes of application - 10 mg/kg of body weight. Ciprofloxacin hydrochloridum 5% solution for i.v. and 1% solution for intraingluvial treatment were prepared. In a crossover study design, ciprofloxacin hydrochloridum was administered as 5 % solution for i.v. bolus injection to broiler chickens and after 14 days as 1 % solution for intraingluvial administration into a crop to the same birds. Serum ciprofloxacin concentrations were assayed by HPLC with UV detection at a wavelength of 279 nm. After intravenous injection the following pharmacokinetic parameters were determined: t1/2b = 9.07 h; t1/2b= 0.36 h; MRT = 10.20 h and MRT = 10.75 h; AUC0→∞= 19.560 mg.h/mL and AUC0→∞ = 19.843 mg.h/mL. After intraingluvial application parameters determined by the two pharmacokinetic models were as: t1/2a= 0.86 h; t1/2b = 7,20 h and t1/2b = 7.89 h; MRT = 12.67 h and MRT = 12.93 h; AUC0→∞ = 11.340 mg.h/mL and AUC0→24h= 11.973 mg.h/mL; Cmax = 2.841 mg/mL and Cmax = 2.638 mg/mL; Tmax = 0.48 h and Tmax = 0.39 h; t1/2abs. = 0.146 h; MAT = 2.47 h and MAT = 2.18 h; F = 57.91% and F = 63.89%. These results suggested that a dose of 10 mg/kg of body weight provides maximum plasma concentration ater intraingluvial administration and is effective in the control of many infectious diseases of poultry.\u

Pharmacokinetics of Ciprofloxacin in Broiler Chickens After Single Intravenous and Intraingluvial Administration