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Sheep have been used äs an aniitial model in experimental perinatology äs well äs in the evaluation of artificial lungs; in both fields a lack of excessive bleeding was observed. The extracorporeal oxygenation of premature lambs was used äs an animal model f or prolonged respiratory support f or the newborn with a membrane oxygenatorv The animal model not only demonstrated excellent oxygenation and C02 removal to the premature lairib, but also seemed to be relatively innoxious to the subject. So it was surprising that the application of the same method led to hemorrhagic conplications. In order to make experiments of the extracorporeal oxygenation of the animal model premature lamb more comparable to the Situation of the newborn human infant, more has to be known about the coagulation System of sheep blood. Coagulation Standards were drawn up from 100 mature female merino-sheep at the age of 2 to 3 years, taken from several herds in Berlin, and corrpared to normal human ranges.

Drawing-up of coagulation standards in sheep – precondition for extracorporeal oxygenation of premature lambs