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"Hemorrhage" in the newborn is a major problem in the adaptation to extrauterine life and has been recognized for some time äs merely a result of Vitamin K deficiency. It is also known that fibrinolysis, especially the balance between the plasminogen-activator and plasmin inhibitor, plays an important role in this disease during the neonatal period. DIC (disseminated in traväscular coagulation), often seen in the pathological newborn infant, has recently been proven äs one of the important factors of the respiratory distress syndrome (RDS) [l, 2, 4, 6, 16]. On the other hand, any imbalance of the acid-base physiology in neonatal asphyxia is a crucial factor in determining whether or not the newborn will survive. With this in mind, attempts were made to correlate these factors throughout the neonatal period. There are two important points in this problem. The first is the relationship between the asphyxia in the newborn and DIC, and the second is the respiratoiy distress syndrome occuring after birth. In order to adapt to extrauterine life, it is necessary for newborn infants to maintain a certain balance in their blood coagulation and fibrinolysis. From this point of view, an investigation of the blood coagulation-fibrinolytic System was performed in the cord-venous blood of cases of asphyxia in relation to various forms of delivery (breech presentation, preeclampsia, cord around the neck, delayed delivery) and respiratory distress syndrome. 2 Material and methods

journal of perinatal medicine

Blood coagulation and fibrinolysis of the newborn viewed as perinatal factors. I. Blood coagulation and fibrinolysis of the newborn viewed as obstetrical factors