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The study of the maternal-fetal passage of drugs and other alien substances, particularly those of potentially hazardous substances of the occupational environment (with quantitative determinations in the blood of the fetal side of the placental vascular System) is an important consideration of perinatal medicine. Therefore, numerous authors (reviews by LEMTIS [18], GAGEL [5], and KIRCHNER [10]) have attempted with their contributions to solve the difficult problem of the physiologically correct perfusion of the placenta. In spite of remarkable advances in the field, the bilateral long-term in vitro perfusion of the human placenta has not yet been accomplished satisfactorily. In part this is due to the failure of systematically studying the potential interferences occurring during perfusion with blood. On the other hand, investigators may have been impeded in their study by the uncertainty as to whether the available placenta was injured or intact. Over several years we have developed in collaboration with GAGEL and following the experimental designs of KRANTZ and coworkers [14, 15, 4, 8, 9, 13] NESBITT et al. [21], as well as HAMRIN et al. [7] a modern apparatus equipped for the bilateral long-term perfusion of spontaneously delivered human placentas [20], stressing the study of both the most favorable experimental conditions as well as possible interfering factors (see also KIRCHNER and LEMTIS [11, 12], During these experiments we designed a test which enables us to determine before the Initiation of Curriculum vitae

A rapid procedure for testing the integrity of the maternal-fetal barrier in spontaneously delivered placentas