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SummaryMaterials and Methods 11 pregnant sheep near term (fetal weight 4.4kg, SD =1.6 kg) were anesthetized with pentobarbital. Electro-magnetic cufF flow meters were put around one uterineartery and the blood flow was measured. The brachialartery and the uterine vein were cannulated. The bloodpressure was measured in these vessels. Blood sampleswere drawn, the oxygen concentrations were measured inthe manometric apparatus of VAN SLYKE. From the uterineblood flow and the AVDO 2 across the uterus the uterineO 2 -uptake was calculated. Results and Conclusions Uterine O 2 -uptake was related to uterine blood flow (Fig. 1). At flow rates above 140 ml min" 1 kg" 1 uterineO 2 -uptake had a value of about 6 ml min 1 kg" 1 . A re-duction of uterine blood flow below 100 ml min" 1 kg" 1 resulted in a proportionale fall of utetine O 2 -uptake. Uterine O 2 -uptake was correlated with uterine vascularresistance (Fig. 3). This indicates that flow reductioncaused by an increased vascular resistance plays animportant role in fetal hypoxia.

Uterine blood flow, oxygen uptake, and vascular resistance of pregnant sheep near term