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Gastrointestinal (GI) hormones are involved in satiety regulation and in glucose metabolism. Most GI hormones are hydrolyzed and inactivated by the same enzyme, dipeptidyl peptidase IV (DPP-IV). We analyzed changes of DPP-IV after weight loss in obese children and its relationships to the GI hormones pancreatic peptide (PP), peptide YY (PYY), and insulin sensitivity.

journal of pediatric endocrinology and metabolism

Changes of Dipeptidyl Peptidase IV (DPP-IV) in Obese Children with Weight Loss: Relationships to Peptide YY, Pancreatic Peptide, and Insulin Sensitivity