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We report the use of anastrozole and bicalutamide in a 5 year-old boy with familial male-limited precocious puberty. Clinical response showed decreased advancement of skeletal maturation, secondary sexual characteristics and aggressiveness with no short-term side effects. The combination seems a better option until long-term data are available.

journal of pediatric endocrinology and metabolism

Treatment of Familial Male-limited Precocious Puberty (Testotoxicosis) with Anastrozole and Bicalutamide in a Boy with a Novel Mutation in the Luteinizing Hormone Receptor